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KMID : 0861020060210020095
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Korea Journal of Herbology
2006 Volume.21 No. 2 p.95 ~ p.101
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Studies on the Cosmeceutical Activities of Perilla frutescens var. acuta
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Choi Eun-Young
An Bong-Jeun
Lee Chang-Eon
Jung Su-hyun
Jang Min-Jung
Cheon Soon-Ju
Sung Ji-Yeun
Kang Bo-Yeon
Joe Woo-A
Jeung Yeun-Suck
Choi Hyang-Ja
Baek Uk-Jin
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Abstract
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Objectives: This study aimed to establish cosmeceutical activities of Perilla frutescens var. acuta.
Methods: Folium Perillae, which had been extracted, concentrated, and freeze drying with water and ethanol, have been used for the experiment. The effects on electronic donating ability, SOD-like activity, xanthine oxidase inhibition, whitening effect have been investigated in the cosmeceutical activity measurement of function experiment.
Results: Both water and ethanol extracts of Perilla frutescens var. acuta showed relatively high electron donating ability of more than 70% at over 500ppm. Also, SOD like activity increased in a dose dependent matter of more than 80% at 5,000ppm, while tyrosinase showed insufficient inhibitory rate. Xanthine oxidase showed a meaningful inhibitory effect of 72.4% in water extract and 55.3% at 1,000ppm in ethanol extract. The addition of $Fe^{2+}ion\;and\;Cu^{2+}ion$ showed relatively high oxidizing inhibitory effect of 57% and 41%, respectively, at 500ppm in water extract and, when $Fe^{2+}$ ion was added in ethanol extract, the effect of 64% at 1,000ppm was achieved. Also, higher oxidizing inhibitory effect was shown against $Fe^{2+}$ rather than $Cu^{2+}$ in both water and ethanol extracts. For human cancer cells, relatively high growth inhibition ability was shown against melanoma G361 in both water and ethanol extracts.
Conclusions: From the above results, it was confirmed that Perilla frutescens var. acuta could be used in functional cosmetics.
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KEYWORD
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Perilla frutescens var. acuta, Cosmeceutical activity
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